APPLICATION OF BIOTECHNOLOGICAL PLANT-BASED PHARMACEUTICAL COMPOSITIONS TO ADDRESS POLYPRAGMASY CHALLENGES IN GERIATRICS
DOI:
https://doi.org/10.32782/health-2024.3.12Keywords:
aging, polypragmasy, flavonoids, active pharmaceutical ingredient, extracts of medicinal plants,Abstract
The article is devoted to the analysis of modern literary data on the pharmacological properties of flavonoids and extracts of biotechnological plant raw materials with a high content of polyphenolic compounds, as well as the prospects of their use in the treatment of age-related diseases. One of the key problems that arise in the treatment of geriatric patients is polypragmasy, that is, the simultaneous use of several drugs, which increases the risk of side effects and reduces the effectiveness of treatment. Several major biomarkers of premature aging, such as oxidative stress and chronic inflammation, are reviewed. The value of aging biomarkers such as telomere shortening, macromolecular damage, and DNA double-strand breaks, which can be targeted for new therapeutic strategies, is shown. An evaluation of the possibilities of using the latest pharmaceutical compositions based on plants of the genera Artemisia, Bidens, and Cichorium, common in Ukraine, containing a wide range of bioactive substances, including flavonoids, was conducted. The latter show significant potential in the fight against aging mechanisms, in particular due to antioxidant, anti-inflammatory, antimicrobial, antidiabetic properties, etc. Particular attention is paid to the geroprotective role of flavonoids in the regulation of molecular mechanisms of oxidative stress and chronic inflammation, which are directly related to the aging process. The prospects of using biotechnological methods for adjusting the quantitative content of bioactive compounds in plant extracts to improve their pharmacological effectiveness are highlighted. The review serves as a basis for increasing the number of studies in the direction of the development of geriatric pharmaceutical compositions that will be able to solve the problems of polypragmasy and polymorbidity.
References
Mercer A.J. Updating the epidemiological transition model. Epidemiology and Infection. 2018. № 146(6). Р. 680–687. doi:10.1017/S0950268818000572
Omran A.R. The epidemiologic transition: A theory of the epidemiology of population change. The Milbank Memorial Fund quarterly. 1971. № 49(4). Р. 509–538. doi:10.2307/3349375
McCallum J., Mathers C. Compression of morbidity. International Encyclopedia of Public Health. 2017. P. 134–141. doi:10.1016/B978-0-12-803678-5.00088-6
Kassis A., Fichot M.C., Horcajada M.N., Horstman A.M.H., Duncan P., Bergonzelli G., Preitner N., Zimmermann D., Bosco N., Vidal K., Donato-Capel L. Nutritional and lifestyle management of the aging journey: A narrative review. Front Nutr. 2023. № 9. Р. 1087505. doi:10.3389/fnut.2022.1087505
Salave S., Patel P., Desai N., Rana D., Benival D., Khunt D., Thanawuth K., Prajapati B. G., Sriamornsak P. Recent advances in dosage form design for the elderly: a review. Expert Opinion on Drug Delivery. 2023. № 20(11). P. 1553–1571. doi:10.1080/17425247.2023.2286368
Eurostat. Ageing Europe – statistics on population developments. Eurostat – Statistics Explained. 2024. https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Ageing_Europe_-_statistics_on_population_developments
The United Nations. World Population Ageing 2019: Highlights – the United Nations. Department of Economic and Social Affairs. Population Division. 2019. https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf
Aggarwal P., Woolford S.J., & Patel H.P. Multi-Morbidity and Polypharmacy in Older People: Challenges and Opportunities for Clinical Practice. Geriatrics. 2020. № 5(4). Р. 85. doi:10.3390/geriatrics5040085
Bezrukov V., Kuprash L., Kuprash O., Gudarenko S. Effectiveness and safety of pharmacotherapy in elderly patients. Short Review. Ageing and Longevity. 2023. № 4(1). Р. 16–21. doi:10.47855/jal9020-2023-1-3
Apaydın K.Ç. Managing Polypharmacy and Deprescribing in Elderly. Primary Health Care. 2022. doi:10.5772/intechopen.99637
Karłowicz-Bodalska K., Sauer N., Jonderko L., Wiela-Hojeńska A. Over the Counter Pain Medications Used by Adults: A Need for Pharmacist Intervention. Int J Environ Res Public Health. 2023. № 20(5). Р. 4505. doi:10.3390/ijerph20054505
Хайтович М.В. Поліфармація: визначення, ризики, менеджмент. Oral and General Health. 2022. № 2(3). Р. 7–12. doi:10.22141/ogh.2.3.2021.240720
Ekiert H., Klimek-Szczykutowicz M., Rzepiela A., Klin P., Szopa A. Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. Molecules. 2022. № 27(19). Р. 6427. doi:10.3390/molecules27196427
Idris O.A., Kerebba N., Horn S., Maboeta M.S, Pieters R. Phytochemical-Based Evidence of the Health Benefits of Bidens Pilosa Extracts and Cytotoxicity. Chemistry Africa. 2023. № 6. Р. 1767–1788. doi:10.1007/s42250-023-00626-2
Matvieieva N., Bessarabov V., Khainakova O., Duplij V., Bohdanovych T., Ratushnyak Y., Kuzmina G., Lisovyi V., Zderko N., Kobylinska N. Cichorium intybus L. "hairy" roots as a rich source of antioxidants and anti-inflammatory compounds. Heliyon. 2023. № 9(3). P. e14516. doi:10.1016/j.heliyon.2023.e14516
Ho T.J., Goswami D., Kuo W.W., Kuo C.H., Yen S.C., Lin P.Y., Lin S.Z., Hsieh D.J., Shibu M.A., Huang C.Y. Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells. Aging. 2022. № 14(15). Р. 6187–6201. doi:10.18632/aging.204210
Rauf A., Khalil A.A., Awadallah S., Khan S.A., Abu-Izneid T., Kamran M., Hemeg H.A., Mubarak M.S., Khalid A., Wilairatana P. Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors-A review. Food science & nutrition. 2023. № 12(2). Р. 675–693. doi:10.1002/fsn3.3784
Lee J., Song C.H. Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian Cells. Antioxidants. 2021. № 10(6). P. 872. doi:10.3390/antiox10060872
Maurya P.K. Animal Biotechnology as a tool to understand and fight aging. Animal Biotechnology. 2020. № 12. P. 235–250. doi:10.1016/b978-0-12-811710-1.00010-0
Maldonado E., Morales-Pison S., Urbina F., Solari A. Aging Hallmarks and the Role of Oxidative Stress. Antioxidants. 2023. № 12(3). P. 651. doi:10.3390/antiox12030651
Yang J., Luo J., Tian X., Zhao Y., Li Y., Wu X. Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases. Antioxidants. 2024. № 13(4). Р. 394. doi:10.3390/antiox13040394
Pizzino G., Irrera N., Cucinotta M., Pallio G., Mannino F., Arcoraci V., Squadrito F., Altavilla D., Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxidative medicine and cellular longevity. 2017. № 2017. Р. 8416763.doi:10.1155/2017/8416763
Liu Z., Zhou T., Ziegler A. C., Dimitrion P., Zuo L. Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications. Oxidative medicine and cellular longevity. 2017. Р. 2525967. doi:10.1155/2017/2525967
Shay J.W., Wright W.E. Telomeres and telomerase: three decades of progress. Nat Rev Genet. № 20. Р. 299–309. doi:10.1038/s41576-019-0099-1
Li X., Li C., Zhang W., Wang Y., Qian P., Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal transduction and targeted therapy. № 8(1). Р. 239. doi:10.1038/s41392-023-01502-8
Лижнюк В.В., Пащенко І.О., Страшний В.В., Бессарабов В.І., Гой А.М., Кузьміна Г.І., Лісовий В.М., Матвєєва Н.А. Дослідження впливу екстракту з «волохатих» коренів Artemisia tilesii на процес утворення супероксидних радикалів у системі автоокиснення адреналіну. Фармацевтичний часопис. 2023. № 3. Р. 42–49. doi:10.11603/2312-0967.2023.3.14167
Michalak M. Plant-derived antioxidants: Significance in skin health and the ageing process. International Journal of Molecular Sciences. 2022. № 23(2). Р. 585. doi:10.3390/ijms23020585
Martínez-Coria H., Arrieta-Cruz I., Gutiérrez-Juárez R., López-Valdés H.E. Anti-Inflammatory Effects of Flavonoids in Common Neurological Disorders Associated with Aging. International journal of molecular sciences. 2023. № 2(5). Р. 4297. doi:10.3390/ijms24054297
Miao Z., Zhao Y., Chen M., He C. Using flavonoids as a therapeutic intervention against rheumatoid arthritis: The known and unknown. Pharmacological Research – Modern Chinese Medicine. 2022. № 3. Р. 100014. doi:10.1016/j.prmcm.2021.100014
Wahnou H., Limami Y., Oudghiri M. Flavonoids and flavonoid-based nanoparticles for osteoarthritis and rheumatoid arthritis management. BioChem. 2024. № 4(1). Р. 38–61. doi:10.3390/biochem4010003
Holloway P.M., Gavins F.N. Modeling Ischemic Stroke In Vitro: Status Quo and Future Perspectives. Stroke. 2016. № 47(2). Р. 561–569. doi:10.1161/STROKEAHA.115.011932
Zhang S., Hu X., Guo S., Shi L., He Q., Zhang P., Yu S., Zhao R. Myricetin ameliorated ischemia/reperfusion-induced brain endothelial permeability by improvement of eNOS uncoupling and activation eNOS/NO. Journal of pharmacological sciences. 2019. № 140(1). Р. 62–72. doi:10.1016/j.jphs.2019.04.009
Le K., Song Z., Deng J., Peng X., Zhang J., Wang L., Zhou L., Bi H., Liao Z., Feng Z. Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation. Inflammation research : official journal of the European Histamine Research Society. 2020. № 69(12). Р. 1201–1213. doi:10.1007/s00011-020-01402-5
Wang C.P., Li J.L., Zhang L.Z., Zhang X.C., Yu S., Liang X.M., Ding F., Wang Z.W. Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-кB signal pathway. Neurochemistry international. 2013. № 63(8). Р. 741–749. doi:10.1016/j.neuint.2013.09.018
Bisht D., Kumar D., Kumar D., Dua K., Chellappan D. K. Phytochemistry and pharmacological activity of the genus artemisia. Archives of pharmacal research. 2021. № 44 (5). Р. 439–474. doi:10.1007/s12272-021-01328-4
El-Taher A.M., Elzilal H.A., Abd El-Raouf H.S., Mady E., Alshallash K.S., Alnefaie R.M., Mahdy E.M. B., Ragab O.G., Emam E.A., Alaraidh I.A., Randhir T.O., Ibrahim M.F.M. Characterization of Some Cichorium Taxa Grown under Mediterranean Climate Using Morphological Traits and Molecular Markers. Plants. 2023. № 12(2). Р. 388. doi:10.3390/plants12020388
Cai F.-J., Wang L., Zhao W., Tian J.-L., Kong D.-G., Liu Q., Sun X.-H., Zhou H.-L. Phytochemical and chemotaxonomic investigations on the whole herbs of Bidens procera L.C.Xu ex X.W. Zheng. Biochemical Systematics and Ecology. 2022. № 101. Р. 104395. doi:10.1016/j.bse.2022.104395
Mashini P., Chihomvu P., Pillay M., Takaidza S. Phytochemical analysis and anti-mycobacterium activity of Bidens pilosa crude extracts. Journal of Biotech Research. 2023. № 2023(15). Р. 116–137.
Ekiert H., Klimek-Szczykutowicz M., Rzepiela A., Klin P., Szopa A. Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. Molecules. 2022. № 27(19). Р. 6427. doi:10.3390/molecules27196427
European Medicines Agency Committee for Veterinary Medicinal Products. Artemisia abrotanum Summary Report. European Medicines Agency: Amsterdam, Netherlands. 1999.
Prezes Urzędu Rejestracji Produktów Leczniczych Wyrobów Medycznych i Produktów Biobójczych. Farmakopea Polska XI Tom II. Polskie Towarzystwo Farmaceutyczne: Warszawa, Poland. 2017.
European Directorate for the Quality of Medicine & HealthCare. European Pharmacopoeia 10.0. Council of Europe: Strasbourg, France. 2021.
Française Pharmacopée. Pharmacopée Française, 11th ed. Noculak, A., Ed.; Georg Olms: Hildesheim, Germany; New York, NY, USA. 2020. № 37.
Street R.A., Sidana J., Prinsloo G. Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evidence-based complementary and alternative medicine : eCAM. 2013. № 2013. Р. 579319. doi:10.1155/2013/579319
Cichorii intybi radix – herbal medicinal product. European Medicines Agency (EMA). 2014. https://www.ema.europa.eu/en/medicines/herbal/cichorii-intybi-radix
Matvieieva N. A., Shakhovsky A. M., Belokurova V. B., Drobot K. O. Artemisia tilesii Ledeb hairy roots establishment using Agrobacterium rhizogenes-mediated transformation. Preparative biochemistry & biotechnology. 2016. № 46(4). Р. 342–345. doi:10.1080/10826068.2015.1031393
Plaskova A., Mlcek J. New insights of the application of water or ethanol-water plant extract rich in active compounds in food. Frontiers in nutrition. 2023. № 10. Р. 1118761. doi:10.3389/fnut.2023.1118761
Godlewska K., Ronga D., Michalak I. Plant extracts – importance in sustainable agriculture. Italian Journal of Agronomy. 2021. № 16(2). doi:10.4081/ija.2021.1851
Баула О.П., Деркач T.M. Забезпечення якості лікарських засобів рослинного походження: стан та перспективи. Фармацевтичний часопис. 2017. № (2). Р. 79–86. doi:10.11603/2312-0967.2017.2.7816
Kowalczewski PŁ, Zembrzuska J. Advances in Biological Activities and Application of Plant Extracts. Applied Sciences. 2023. № 13(16). P. 9324. doi:10.3390/app13169324
Migliorini A.A., Piroski C.S., Daniel T.G., Cruz T.M., Escher G.B., Vieira do Carmo M.A., Azevedo L., Marques M.B., Granato D., Rosso N.D. Red Chicory (Cichorium intybus) Extract Rich in Anthocyanins: Chemical Stability, Antioxidant Activity, and Antiproliferative Activity In Vitro. Journal of food science. 2019. № 84(5). Р. 990–1001. doi:10.1111/1750-3841.14506
Chandra K., Jain V., Jabin A., Dwivedi S., Joshi S., Ahmad S., Jain S. K. Effect of Cichorium intybus seeds supplementation on the markers of glycemic control, oxidative stress, inflammation, and lipid profile in type 2 diabetes mellitus: A randomized, double-blind placebo study. Phytotherapy research : PTR. 2020. № 34(7). Р. 1609–1618. doi:10.1002/ptr.6624
Rodríguez-Mesa X.M., Contreras Bolaños L.A., Mejía A., Pombo L.M., Modesti Costa G., Santander González S.P. Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review. Pharmaceutics. 2023. № 15(5). Р. 1491. doi:10.3390/pharmaceutics15051491
Matvieieva N.A., Duplij V.P., Ratushnyak Ya.I. The effect of the temperature stress on the growth and content of bioactive compounds in the «hairy» roots bidens pilosa L. Fiziologia Rastenij i Genetika. 2023. № 55(5). Р. 417–425. doi:10.15407/frg2023.05.417
Santos-Beneit F. What is the role of microbial biotechnology and genetic engineering in medicine? MicrobiologyOpen. 2024. № 13(2). Р. e1406. doi:10.1002/mbo3.1406
Ying W., Wen G., Xu W., Liu H., Ding W., Zheng L., He Y., Yuan H., Yan D., Cui F., Huang J., Zheng B., Wang X. Agrobacterium rhizogenes: paving the road to research and breeding for woody plants. Frontiers in plant science. 2023. № 14. Р. 1196561. doi:10.3389/fpls.2023.1196561
Bohdanovyсh T., Shakhovsky A., Duplij V., Ratushnyak Y., Kuchuk M., Poyedinok N., Matvieieva N. Effects of the genetic transformation on the antioxidant activity of Althaea officinalis L., Artemisia vulgaris L. and Artemisia tilesii Ledeb. «hairy» roots. Cytology and Genetics. 2021. № 55(6). Р. 531–539. doi:10.3103/S0095452721060037
Gantait S., Mukherjee E. Hairy root culture technology: applications, constraints and prospect. Appl Microbiol Biotechnol. 2021. № 105. Р. 35–53. doi:10.1007/s00253-020-11017-9
Blank D., Demuner A., Carvalho J., Firmino M., Figueiredo T., Souza G., Zocolo G., Guedes J., Faria D., Vieira L., Soares J., Fortini E., Santos M., Otoni W. Agrobacterium rhizogenes-mediated transformation of Crotalaria ochroleuca: Production of flavonoids from hairy roots. Journal of the Brazilian Chemical Society. 2023. № 34(12). Р. 1898-1908. doi:10.21577/0103-5053.20230083
Mottaki Z., Rezayian M., Niknam V, Ebrahimzadeh H., Mirmasoumi M. Using hairy roots for production of secondary metabolites in Artemisia. Plant Biotechnol Rep. 2019. № 13. Р. 263–271. doi:10.1007/s11816-019-00534-3
Janda K., Gutowska I., Geszke-Moritz M., Jakubczyk K. The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties-A Review. Molecules. 2021. № 26(6). Р. 1814. doi:10.3390/molecules26061814
Hanafy M.S., Asker M.S., El-Shabrawi H., Matter M.A. Agrobacterium Rhizogenes-mediated genetic transformation in Cichorium spp.: Hairy root production, inulin and total phenolic compounds analysis. The Journal of Horticultural Science and Biotechnology. 2018. № 93(6). Р. 605–613. doi:10.1080/14620316.2017.1420429
