EVALUATION OF THE RHEOLOGICAL PROPERTIES OF OINTMENT WITH EXTRACTS OF CHELIDONIUM MAJUS AND CALENDULA OFFICINALIS ON A NATURAL BASIS
DOI:
https://doi.org/10.32782/health-2025.1.13Keywords:
ointment, soft medicinal products, pharmaceutical development, greater celandine (Chelidonium majus L.), medicinal plant raw materials, calendula (Calendula officinalis L.), beekeeping products, rheological studiesAbstract
At present, the pharmaceutical market for herbal medicinal products is regulated by Directive 2004/24/EC on traditional herbal medicinal products, which establishes a strategy for the development of medicinal products containing plant-based raw materials with a long history of use. Guided by the principles of Directive 2004/24/EC, the development of an ointment containing oil extracts of greater celandine (Chelidonium majus L.) and calendula flowers (Calendula officinalis L.), with the addition of native propolis, has been justified for external use to meet the needs of the Armed Forces of Ukraine.For the preparation of the ointment, beeswax was used, which, in combination with oil extracts, ensures an ointment- like consistency. The manufacturing technology was adapted to household conditions, making it easily reproducible.The article presents the results of a study on the rheological properties of an ointment developed for use by military personnel to accelerate wound healing, treat cuts, and manage dermatological conditions. An analysis of the structural and mechanical characteristics of the product was conducted, including viscosity, thixotropic properties, and plastic deformation. The optimal parameters of the ointment base were determined to ensure convenient application, uniform distribution, and prolonged action of active ingredients.The assessment of the consistency properties of the ointment was carried out through rheological studies under the influence of variable temperature factors and mechanical stress affecting the structure of the ointment. The conducted studies indicate the colloidal and thermal stability of the ointment and demonstrate its high spreadability and ease of distribution on the skin surface.
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