STUDY OF THE INFLUENCE OF CARRIER BASES ON THE BIOPHARMACEUTICAL PROPERTIES OF THE TOPICAL PHARMACOTHERAPEUTIC PRODUCT WITH 2-(((3-(2-FLUOROPHENYL)- 5-MERCAPTO-4H-1,2,4-TRIAZOLE-4-YL)IMINO)METHYL)PHENOL FOR DERMATOLOGICAL HELP

Abstract

Mycosis of the foot, known as a fungal infection of the foot, is a fairly common disease, especially those who are in combat (both servicemen and civilians). Therefore, the development of new topic drugs can expand the possibility of therapy of foot mycosis for patients with contraindications to systemic drugs. Development of cream on the basis of 2-(((3-(2-fluorophenyl)-5-mercapto-4h-1,2,4-triazole-4-yl)imino)methyl)phenol for the treatment and prevention of foot mycosis is a promising area of pharmacy. The creation of such a topic drug will expand the arsenal of effective means of domestic production capable of competing with imported counterparts. This work aims to justify the choice of the optimal base – the carrier for the topical pharmacotherapeutic agent containing the above active substance. The study used specially selected bases for a local drug with antifungal activity. These basics were selected in such a way as to maximize the effectiveness of the drug and minimize the risk of side effects. The main selection criteria were safety for the skin, convenience of use and scientific substantiation of their properties. A series of experiments was intended to check the stability of the developed compositions. All samples made under identical conditions have been tested for stratification resistance under the influence of temperatures and centrifugal forces. The results showed that the compositions retain their properties and do not stratify under such conditions, which allows you to move to the next stage of development. Studies have shown that for better release of the active substance, the most suitable is the emulsion basis of the type “oil/water”.