VITAMIN D DEFICIENCY AS A TRIGGER OF THE DEVELOPMENT OF AUTOIMMUNE DISEASES
DOI:
https://doi.org/10.32782/health-2023.2.13Keywords:
deficiency/insufficiency of cholecalciferol, autoimmune process, autoimmune disease, immune response.Abstract
The article discusses the pathogenetic changes that occur in the body against the background of vitamin D deficiency and their impact on the possible development of autoimmune diseases. The relationship between the occurrence of autoimmune processes in the body and a deficiency of vitamin D has been clarified. The relevance of the topic of the article is that vitamin D plays an important role in maintaining the good health of the human body. Vitamin D deficiency exists in every region of the world. In the European population, vitamin D insufficiency is greater in the south than in the north and is more likely in women than in men; women with osteoporosis are vitamin D deficient in 50% of cases. More than 80% of Ukrainians are deficient in vitamin D. According to the WHO, this figure reaches 88% in the world. Today, WHO considers 25(OH)D insufficiency and deficiency to be a pandemic, affecting a large part of the general population, including children and adolescents, pregnant and lactating women, adults, menopausal women, and the elderly. In the presence of an osteoporotic fracture, the prevalence of vitamin D deficiency can reach 100%. The reasons for the occurrence and development of the autoimmune process in the body against the background of a lack or deficiency of vitamin D were considered. The authors found out exactly which changes caused by the lack or deficiency of cholecalciferol in the body are favourable factors for the development of autoimmune diseases or the worsening of the course of already existing autoimmune diseases with the development of complications. The authors of the article came to the conclusion that the lack and deficiency of vitamin D, currently a global problem for all mankind, is a so-called “pandemic,” leads to violations of the normal functioning of all organs and systems of the body, and also acts as a trigger in the development of autoimmune diseases and contributes to the deterioration course with the development of complications of already existing diseases.
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