COMPARATIVE STUDY OF THE CONTENT OF THE MAIN GROUPS OF BIOLOGICALLY ACTIVE SUBSTANCES IN PHYTOCOMPLEXES FOR NORMALIZATION OF THE FUNCTIONAL STATE OF FEMALE REPRODUCTIVE ORGANS
DOI:
https://doi.org/10.32782/health-2025.2.13Keywords:
phytocomplex, herbal medicine, quantitative content, phytoestrogens, menstrual disorders, women’s reproductive health, hormonal balanceAbstract
The aim of the work. A comparative study of the quantitative content of key biologically active compounds in phytocomplexes aimed at normalizing the functional state of female reproductive organs from various manufacturers available in the domestic pharmaceutical market.The study was conducted on a group of phytocomplexes derived from Symplocosum and Asparagus, sourced from different manufacturers: Normocycle (Organosin Ltd), Femicycle (Ananta Medicare Ltd), and Tazalok (Pro- Pharma). The quantitative determination of the main groups of biologically active substances was performed using UV spectrophotometry. This included measuring the amount of phenolic compounds (expressed as gallic acid), flavonoids (expressed as rutin), and hydroxycinnamic acids (expressed as chlorogenic acid).In terms of phenolic compounds, the levels in Normocycle and Tazalok were similar, although Normocycle showed a slightly higher content. The difference between Normocycle and Femicycle was more pronounced. Tazalok had the highest concentration of flavonoids, being nearly 1.7 times greater than that found in both Normocycle and Femicycle. Additionally, Normocycle contained 20 % more hydroxycinnamic acids than Tazalok, and more than 1.7 times the amount found in Femicycle. Overall, in terms of the quantitative content of the total active compounds responsible for the pharmacological effects, Normocycle and Tazalok outperformed Femicycle in a single dose of the phytocomplex. The analysis of the quantitative content of bioactive substances responsible for pharmacological effects in a single dose of the studied herbal medicines revealed that Normocycle contains the highest levels of phenolic compounds and hydroxycinnamic acids. However, it has a lower total content of flavonoids compared to Tazalok. Both Normocycle and Tazalok significantly surpass Femicycle in terms of the quantity of active components present in one dose of these phytocomplexes.
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