CARBOHYDRATE-LIPID INDICES – TRIGLYCERIDE-GLUCOSE INDEX AND MCAULEY INDEX IN PATIENTS WITH CARDIORENAL METABOLIC SYNDROME
DOI:
https://doi.org/10.32782/health-2025.3.20Keywords:
triglyceride-glucose index, McAuley index, cardiorenal metabolic syndrome, insulin resistance, hyperglycemia, hyperinsulinemiaAbstract
Complex indicators which characterize both carbohydrate and lipid metabolism can be used for a comprehensive assessment of metabolic glycolipid metabolism/ These indecators are triglyceride-glucose index (TGGI) and McAuley index (MAI). The aim was to evaluate the levels of the TGGI and MAI in patients with cardiorenal metabolic syndrome (CRMs) and to determine their correlations. Materials and methods. 100 patients with acute forms of coronary artery disease were examined. They were divided into groups (G0, G1, G2, G3) according stages of CRMs. Investigation was provided in compliance with the Helsinki Declaration of Human Rights. Some indicators were additionally determined in addition to TGGI and MAI: HOMA-IR; %Bcalc; %S; IR; QUICKI; Gutt; Cederholm; Matsuda; Avignon; Shuster; DI DeFronzo; Drivsholm; Stumvoll early and late; Wareham; atherogenic index (AI); TG/HDL ratio and Castelli I index. The results were statistically processed, presented as M±m. Correlation analysis was performed using Spearman-Pearson method, and the significance level was set at p<0.05. Results. The value of TGGI was minimal in patients without renal dysfunction, and in G1 and G2 it was significantly higher (5.73 and 4.41; both p<0.05). The value of MAI increased as renal function deteriorated. The MAI and the TGGI were inversely correlated with each other under all stages of CRMs. An increase of TGGI and a decrease of MAI were unfavorable. These indices substantially correlated with atherogenic lipid metabolism parameters, hyperglycemia, hyperinsulinemia, insulin resistance, and a decrease of the hepatic and peripheral tissue insulin sensitivity. The TGGI and the MAI were various in different stages of CRMs. Conclusions. Triglyceride-glucose index and McAuley index correlated with lipid metabolism parameters, hyperglycemia, hyperinsulinemia, and insulin resistance in patients with cardiorenal metabolic syndrome. An increase of TGGI and a decrease of McAuley index were unfavorable.
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