ASPECTS OF THE DEVELOPMENT OF THE PACKAGE FOR PHARMACEUTICAL PRODUCT BASED ON MALVA SYLVESTRIS L. EXTRACT
DOI:
https://doi.org/10.32782/health-2023.4.18Keywords:
Malva sylvestris L., flavonoids, container, package, GMP, synthetic and natural plastic, glass, metals, sterilityAbstract
The main function of the primary package is the protection and safety of finished pharmaceuticals that come into direct contact. Good manufacturing practice (GMP) regarding packaging were first introduced in the 1980s to establish the requirements for materials, manufacturing processes, and quality control. These standards consider minimum requirements for creating safe products. Modern development strategies provide the possibility of recycling, reducing the amount of waste, protecting the environment, and eliminating harm to the environment because packaging materials should not be toxic during production, processing, storage, or utilization. Common mallow (Malva sylvestris L.), a plant belonging to the Malvaceae family, is known for its anti-inflammatory and antioxidant properties. The largest amount of flavonoids and their derivatives is extracted from the shout of plants, which are sensitive to the influence of oxygen and light and quickly decompose; therefore, it is extremely important to ensure the tightness of the packaging and protection from light. In this work, we describe the selection of the primary package for medication based on a common mallow that is currently under development or is patented. Therefore, bottles, blisters, and ampoules were chosen. Materials for packaging can be divided into three groups: plastics (synthetic and natural), which are the most popular owing to their lightness and strength. It is necessary to avoid adsorptive and toxic species; among the advantages of glass, we can highlight resistance to the drug and resistance to corrosion, the main disadvantage of this material is its fragility and the largest weight among the possible options, which makes it difficult to transport, store, and use by the patient; metals are used mostly for blisters, are strong and resistant to corrosion, but are often harmful to the compounds of the product.
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