HYPERURIKEMIA IS NOT ONLY GOUT

Abstract

The severity of gout and the risk of its occurrence largely depend on the duration and degree of hyperuricemia (DH). However, the vast majority of patients with asymptomatic DH do not have clinical signs of gout. There is substantial evidence that asymptomatic DH is pathogenetically associated with cardiovascular disease, including hypertension, especially in postmenopausal women. The purpose of the study was to analyze the features of the course of hypertension in combination with the menopausal syndrome and to evaluate the relationship of asymptomatic DH depending on the clinical course of the menopausal syndrome. We examined 105 women with stage II hypertension combined with menopausal syndrome, who made up the main group. The control group – 20 patients with hypertension stage II without manifestations of menopausal syndrome. The average age of patients in the main group was 51±1.8 years, the control group was 52±2.4 years. According to the anamnesis, the duration of hypertension in the examined patients of the main group was 7.8±1.1 years, in patients of the control group – 7.9±1.3 years. All patients were in the menopausal period. The results of the study demonstrate that the presence of menopausal syndrome in women not only subjectively, but also objectively worsens the clinical course of hypertension. It was established that the level of office systolic and diastolic blood pressure (BP), changes in the daily profile of BP, and an increase in the frequency of hypertensive crises depend on the severity of the course of the menopausal syndrome and are more pronounced in patients with a more severe course. It is shown that in this category of women there is an increase in the level of asymptomatic DH with an increase in the severity of the menopausal syndrome. Evidence of the relationship between asymptomatic DH and the features of the course of the menopausal syndrome in women with hypertension dictates the need for its timely diagnosis and correction.